Generalized Estimating Equation (GEE) is a marginal model popularly applied for longitudinal/clustered data analysis in clinical\ntrials or biomedical studies.We provide a systematic review on GEE including basic concepts as well as several recent developments\ndue to practical challenges in real applications.The topics including the selection of ââ?¬Å?workingââ?¬Â correlation structure, sample size\nand power calculation, and the issue of informative cluster size are covered because these aspects play important roles in GEE\nutilization and its statistical inference. A brief summary and discussion of potential research interests regarding GEE are provided\nin the end.
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